Key result
Stage 1 pressure injury in diabetics is linked to ~190% higher one-year PAOD risk.
Why the study?
Diabetes is often complicated by pressure injury, peripheral arterial occlusive disease, amputation, and mental illness, impairing quality of life and increasing healthcare demands.
Is Stage 1 Pressure Injury associated with increased risk of PAOD, amputation, mental illness, and mortality in diabetic patients?
Cohort (n=15,394)
Yes
Is Stage 1 Pressure Injury associated with increased risk of PAOD, amputation, mental illness, and mortality in diabetic patients?
Stage 1 pressure injury in diabetic patients is a significant risk marker for subsequent peripheral arterial occlusive disease and amputation.
Answers are grounded in this paper and cite their sources.
May flag high-risk diabetic patients for vascular monitoring; leaves open causal links and need for prospective trials.
Diabetes mellitus is a global health burden often complicated by Stage 1 Pressure Injury (PI), Peripheral Arterial Occlusive Disease (PAOD), amputation, and mental illness. These complications impair quality of life and increase healthcare demands. This study examined the associations among PI, PAOD, amputation, and mental illness in diabetic patients to enhance clinical strategies. A retrospective cohort study was conducted using TriNetX multicenter data from 2014 to 2023. Diabetic patients with or without Stage 1 PI were analyzed. Kaplan-Meier survival analysis estimated hazard ratios (HRs) and 6-month all-cause mortality for PAOD, amputation, and mental illness. Among 7697 diabetic patients, the HR for PAOD rose from 2.74 to 2.90, while mortality decreased slightly. The HR for amputation increased from 2.74 to 4.24, with minimal change in mortality. Mental illness risk slightly decreased (HR from 1.91 to 1.88), with a moderate reduction in mortality. First-degree PI in diabetic patients is associated with higher risks of PAOD and amputation, and slightly lower risk for mental illness. Early screening and prevention for at-risk individuals are essential to reduce complications and improve outcomes.
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Chen et al. (2026) conducted a cohort in Diabetes mellitus (n=15,394). Stage 1 pressure injury vs. No pressure injury was evaluated on Peripheral Arterial Occlusive Disease (PAOD) at 1 year (HR 2.90, 95% CI 2.45-3.44, p=0.602). Stage 1 pressure injury in diabetic patients significantly increased the one-year risk of peripheral arterial occlusive disease (HR 2.90), amputation (HR 4.24), and mental illness (HR 1.88).
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