Key result
LVEF < 40% linked to ~4-fold higher odds of RV systolic dysfunction in left heart failure.
Why the study?
Right ventricular dysfunction affects outcomes in patients with left heart failure, prompting an assessment of the determinants of right ventricular systolic dysfunction in this population.
Cross-Sectional (n=270)
No
Odds Ratio: 4.205 (95% CI 1.643–10.76)
p-value: p=0.003
In a Ghanaian cohort with left heart failure, right ventricular systolic dysfunction was highly prevalent (75.2%) and was independently predicted by reduced LVEF, restrictive LV filling, elevated pulmonary pressures, and lower systolic blood pressure.
LVEF <40% may flag higher RV dysfunction risk in left HF; leaves open whether integrated assessment improves outcomes.
BACKGROUND: The presence of right ventricular dysfunction affects outcomes in patients with left heart failure. We assessed the determinants of right ventricular systolic dysfunction (RVSD) among patients with left heart failure presenting to the Korle Bu Teaching Hospital of Ghana. METHODS: Consecutive patients with left heart failure who were 18 years and above were prospectively enrolled and assessed for evidence of RVSD by measuring the tricuspid annular plane systolic excursion, the peak velocity of the tricuspid annulus in systole (RV S'), the two-dimensional right ventricular fractional area change (RV FAC) and the right ventricular myocardial performance index (RV MPI). CONCLUSIONS: RVSD was common in these Ghanaian patients with left heart failure. Left ventricular function, SBP and PASP were independent predictors of the presence of RVSD. Pending further validation, the LVOT VTI may serve as a useful surrogate or screening tool for RVSD in these patients.
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Yakubu et al. (2023) conducted a cross-sectional in Left heart failure (n=270). Left ventricular ejection fraction < 40% vs. Left ventricular ejection fraction ≥ 40% was evaluated on Right ventricular systolic dysfunction (RVSD) (OR 4.205, 95% CI 1.643-10.760, p=0.003). Left ventricular ejection fraction < 40% was independently associated with a four-fold increased odds of right ventricular systolic dysfunction (OR 4.205) in patients with left heart failure.
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