Key result
Preclinical animal models of cardiovascular complications of pregnancy, including preeclampsia and peripartum cardiomyopathy, provide crucial insights into pathological mechanisms of human disease.
Why the study?
Cardiovascular complications of pregnancy cause the majority of pregnancy-induced maternal deaths, but their causes and pathophysiology remain poorly understood and therapeutic options are limited.
This review summarizes advances in preclinical models of pregnancy-related cardiovascular complications, such as preeclampsia and peripartum cardiomyopathy, to better understand their pathophysiology.
Answers are grounded in this paper and cite their sources.
May inform mechanistic research but should not guide clinical care; leaves open human validation of model-derived insights.
Cardiovascular complications of pregnancy have risen substantially over the past decades, and now account for the majority of pregnancy-induced maternal deaths, as well as having substantial long-term consequences on maternal cardiovascular health. The causes and pathophysiology of these complications remain poorly understood, and therapeutic options are limited. Preclinical models represent a crucial tool for understanding human disease. We review here advances made in preclinical models of cardiovascular complications of pregnancy, including preeclampsia and peripartum cardiomyopathy, with a focus on pathological mechanisms elicited by the models and on relevance to human disease.
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Arany et al. (2022) conducted a review in Cardiovascular complications of pregnancy (preeclampsia, peripartum cardiomyopathy). Preclinical animal models was evaluated. Preclinical animal models of cardiovascular complications of pregnancy, including preeclampsia and peripartum cardiomyopathy, provide crucial insights into pathological mechanisms of human disease.
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