Key result
Compound 45 inhibits RSV replication with a selectivity index up to ~1147 in preclinical testing.
Triazole-linked 7-hydroxycoumarin-monoterpene conjugates, particularly Compound 45, show potent in vitro inhibition of RSV replication, likely targeting the RSV F protein.
Hypothesis-generating for RSV antivirals; leaves open clinical translation pending further studies.
in the low micromolar or submicromolar range of concentrations. These are the most active coumarin derivatives found so far. Compound 45 combining 3,7-dimethyloctane and cyclopentane-annealed coumarin fragments has a selectivity index of 160 for serotype A and 1147 for serotype B. According to the results of the time-of-addition experiments, the conjugates are active at the early stages of the virus cycle. Based on biological evaluation and molecular modeling data, RSV F protein is a possible target.
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Tsypyshev et al. (2024) studied RSV replication. triazole-linked 7-hydroxycoumarin-monoterpene conjugates (Compound 45) was evaluated on RSV replication inhibition (selectivity index). Compound 45, a triazole-linked 7-hydroxycoumarin-monoterpene conjugate, inhibited RSV replication with a selectivity index of 160 for serotype A and 1147 for serotype B.
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