Beta-Strand Mimetics

An overview of recent progress made toward nonpeptidic β-strand scaffolds is given. Reports between 1990-2003 are considered as well as few examples from broader reviews on peptide secondary structure. Focus is on inhibitors reported in crystallographic structures of protease-ligand complexes. Scaffolds are classified principally based on their heterocyclic subunits, although they may be perceived as amino acid surrogates elsewhere. An encyclopedia-style organization is adopted, according to compound class, to facilitate finding compounds, to identify structural similarities and differences, and particularly to compare different chemical types of β-stran mimetics.