PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
November 1, 1973Circulation ResearchOpen Access

Spontaneous and Induced Cardiac Arrhythmias in Subendocardial Purkinje Fibers Surviving Extensive Myocardial Infarction in Dogs

View Full Paper
Ask AI
Bookmark
Share

Population

Isolated, superfused infarcted myocardium excised from dogs previously subjected to a two-stage ligation of…

Design

Preclinical

Follow-up

24 hours after coronary occlusion (time of excision)

Authors

PFPeter L. FriedmanJSJames R. StewartAWAndrew L. Wit

Discussion

Loading...

Member takes

Overview

May underlie early post-MI ventricular arrhythmias; leaves open clinical translation from animal models.

Key Points

  • To investigate the electrophysiological mechanisms of ventricular arrhythmias associated with myocardial infarction in canine models.
  • Studied isolated, superfused infarcted myocardium from dogs with anterior descending coronary artery ligation.
  • Conducted electrophysiological measurements using intracellular microelectrodes on surviving subendocardial Purkinje fibers after myocardial infarction.
  • Rapid, repetitive depolarizations observed in surviving Purkinje fibers, either spontaneously or induced by premature stimulation.
  • Premature stimulation led to conduction block in infarcted regions and reentrant beats.
  • Some Purkinje fibers exhibited spontaneous diastolic depolarization, functioning as pacemakers.

Structured PICO

P
Population
Isolated, superfused infarcted myocardium excised from dogs previously subjected to a two-stage ligation of the anterior descending coronary artery
I
Intervention
Intracellular microelectrode study in vitro with premature electrical stimulation
O
Outcome
Electrophysiological characteristics of surviving subendocardial Purkinje fibers (arrhythmias, action potential duration, conduction block, pacemaker activity)surrogate

Surviving subendocardial Purkinje fibers in infarcted myocardium exhibit abnormal electrophysiological properties that may serve as the origin for ventricular arrhythmias post-myocardial infarction.

Cite This Study

Friedman et al. (1973) studied this question.

synapsesocial.com/papers/6a19d085e7f8932c5eeaba30https://doi.org/10.1161/01.res.33.5.612
View Full Paper
Ask AI
Bookmark
Share