Key result
Rapid ventricular epicardial stimulation induced sustained ventricular arrhythmias in dogs with acute myocardial infarction but not in controls, supporting a re-entry mechanism around the infarction.
Why the study?
Does rapid ventricular epicardial stimulation induce sustained ventricular arrhythmias in dogs with acute myocardial infarction compared to controls?
Population
16 dogs (8 dogs 5 days after coronary artery ligation and 8 controls)
Comparison
Rapid ventricular epicardial stimulation vs Control dogs without coronary artery ligation
Design
Preclinical
Authors
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Supports re-entry around infarction in acute MI models; leaves open human translation and therapeutic implications.
Does rapid ventricular epicardial stimulation induce sustained ventricular arrhythmias in dogs with acute myocardial infarction compared to controls?
This preclinical study demonstrates that acutely damaged myocardial tissue following infarction facilitates sustained ventricular arrhythmias via re-entry circuits.
Kaplinsky et al. (1972) studied Acute myocardial infarction and ventricular arrhythmias (n=16). Rapid ventricular epicardial stimulation vs. Control dogs without coronary ligation was evaluated on Post stimulation ventricular arrhythmias. Rapid ventricular epicardial stimulation induced sustained ventricular arrhythmias in dogs with acute myocardial infarction but not in controls, supporting a re-entry mechanism around the infarction.
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