Key result
High plasma CCL21 is linked to ~164% higher risk of first-time coronary events.
Why the study?
Associations between the homeostatic chemokines CCL21 or CCL19 and first-time coronary event incidence had not been investigated previously in populations without established cardiovascular disease.
Do plasma levels of CCL21 and CCL19 predict future coronary events in individuals without previous coronary heart disease?
Population
General population from the Malmö Diet and Cancer cohort (nested case-control n = 676, cohort n = 4636)
Comparison
Plasma levels of CCL21 or CCL19
Design
Prospective population-based cohort and nested case-control study
Follow-up
Two decades
Authors
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May inform primary prevention risk stratification; extends CCL21 biomarker observations from secondary to incident coronary disease.
Cohort (n=4,636)
No
Do plasma levels of CCL21 and CCL19 predict future coronary events in individuals without previous coronary heart disease?
Odds Ratio: 2.64 (95% CI 1.62–4.31)
p-value: p=<0.001
Plasma CCL21 levels independently predict future first-time coronary events in individuals without a history of coronary heart disease, suggesting its potential utility as a biomarker for cardiovascular risk prediction.
Katra et al. (2023) conducted a cohort in First-time coronary events (n=4,636). High plasma CCL21 levels vs. Lowest tertile of plasma CCL21 was evaluated on Incident first-time coronary events (OR 2.64, 95% CI 1.62-4.31, p=<0.001). High plasma levels of CCL21 were associated with incident first-time coronary events independently of traditional risk factors (OR 2.64), whereas CCL19 was not.
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