Adults aged 65-74 years with asymptomatic carotid artery stenosis performed significantly worse on the Short Physical Performance Battery compared to those without stenosis.
Cross-Sectional (n=709)
Does asymptomatic carotid artery stenosis reduce mobility function in community-dwelling older adults?
Asymptomatic carotid artery stenosis is associated with significantly worse mobility function in older adults aged 65-74 years, suggesting it may be a contributor to preclinical mobility decline.
Absolute Event Rate: 9.81% vs 11.1%
p-value: p=<0.0001
Background Older adults with mobility dysfunction are at risk for falls, hospitalization, and death. In an earlier pilot study, individuals with asymptomatic carotid artery stenosis (ACAS) demonstrated mobility dysfunction when compared to individuals without ACAS. We tested whether carotid stenosis affected mobility function in a larger community-dwelling cohort using the Invecchaire in Chianti (InCHIANTI) database. Methods We analyzed data from participants in the InCHIANTI study who completed a medical history, carotid duplex testing, and mobility function testing (Short Physical Performance Battery- SPPB). Participants with a history of stroke, transient ischemic attack, or carotid endarterectomy were excluded. 709 participants met inclusion criteria (116 ACAS, 593 no ACAS). Our analytic approach sought to evaluate the impact of stenosis on mobility after accounting for age, sex and cardiovascular risk factors. Age was stratified into 2 age-groups (65-74 and 75-84 years). Two-way ANOVA was used to test the effect of stenosis-group, age-group, and their interactions on SPPB score with sex as a covariate. Results Stenosis-group ( P = 0.0002), age-group ( P < 0.0001), and the interaction between stenosis-group and age-group ( P = 0.0008) significantly affected SPPB. Post-hoc testing showed that participants with ACAS demonstrated worse performance on the SPPB (9.81 ± 0.37) compared to those with no ACAS (11.10 ± 0.11) in the 65-74 years age-group ( P < 0.0001). Conclusions 65-74-year-old adults with ACAS performed significantly worse on the SPPB than those without ACAS. These results lend further support that ACAS may be associated with mobility dysfunction in older adults.
Desikan et al. (Thu,) conducted a cross-sectional in Asymptomatic Carotid Artery Stenosis and Mobility Dysfunction (n=709). Asymptomatic carotid artery stenosis (ACAS) vs. No asymptomatic carotid artery stenosis was evaluated on Short Physical Performance Battery (SPPB) score in the 65-74 years age-group (p=<0.0001). Adults aged 65-74 years with asymptomatic carotid artery stenosis performed significantly worse on the Short Physical Performance Battery compared to those without stenosis.