What does this research mean for the field?

Cellular IRES-mediated translation, regulated by the competitive action of IRES-transacting factors (ITAFs), is favored during stress conditions when cap-dependent translation is compromised and plays a pivotal role in determining cell-fate decisions such as pro-survival adaptation or cell death. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 14, 2011Cell CycleOpen Access

Cellular IRES-mediated translation

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Population

Eukaryotic cells

Design

Review

Authors

AKAnton A. KomarCleveland State University MHMaria HatzoglouUniversity School

Discussion

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Implication

ITAFS may shape cardiac cell survival under stress; leaves open targeted interventions pending mechanistic and clinical validation.

Structured PICO

Population

Eukaryotic cells

This review highlights the role of IRES-mediated translation and IRES-transacting factors in controlling cell-fate decisions during stress conditions.

Cite This Study

Komar et al. (2011) studied this question.

synapsesocial.com/papers/6a19da3a196cd56b09eacffb https://doi.org/10.4161/cc.10.2.14472

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Cellular IRES-mediated translation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cellular IRES-mediated translation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider