What does this research mean for the field?

Hypoxia and ischemia induce calcineurin-mediated dephosphorylation and translocation of the Kv2.1 channel, enhancing delayed rectifier potassium currents to suppress neuronal excitability and confer neuroprotection. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 30, 2005Journal of NeuroscienceOpen Access

Calcium- and Metabolic State-Dependent Modulation of the Voltage-Dependent Kv2.1 Channel Regulates Neuronal Excitability in Response to Ischemia

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Population

Rat brains (subjected to CO2 inhalation or global ischemia) and cultured embryonic rat hippocampal neurons

Comparison

Hypoxia/ischemia vs Control conditions

Design

Preclinical

Authors

HMHiroaki MisonouUniversity of Maryland, Baltimore DMDurga P. MohapatraNational Institutes of Health MMMilena MenegolaUniversity Hospital of Basel

Discussion

Member takes

Implication

Should not yet inform clinical stroke care; leaves open Kv2.1 modulation as neuroprotective target in ischemia.

Structured PICO

Population

Rat brains (subjected to CO2 inhalation or global ischemia) and cultured embryonic rat hippocampal neurons

Intervention

Hypoxia/ischemia (CO2 inhalation, global ischemia, or chemical ischemia with 2-deoxy-D-glucose and sodium azide)

Comparator

Control conditions (normoxia, no chemical ischemia)

Outcome

Phosphorylation state and subcellular localization of Kv2.1 channels, and delayed rectifier currents (IK)surrogate

Dynamic modulation of Kv2.1 channels in response to hypoxia/ischemia suppresses neuronal excitability, suggesting a novel neuroprotective mechanism during brief ischemic insults.

Cite This Study

Misonou et al. (2005) studied this question.

synapsesocial.com/papers/6a19dafa4b45427442ead10b https://doi.org/10.1523/jneurosci.3370-05.2005

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Calcium- and Metabolic State-Dependent Modulation of the Voltage-Dependent Kv2.1 Channel Regulates Neuronal Excitability in Response to Ischemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Calcium- and Metabolic State-Dependent Modulation of the Voltage-Dependent Kv2.1 Channel Regulates Neuronal Excitability in Response to Ischemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider