Why the study?
Does HTLV-I carrier status affect lymphocyte phenotypes and IgG levels in healthy children?
Does HTLV-I carrier status affect lymphocyte phenotypes and IgG levels in healthy children?
HTLV-I infection may alter the immune system in healthy carrier children, as evidenced by decreased CD8+CD57+ lymphocytes and increased IgG levels.
Immune differences in healthy pediatric HTLV-I carriers should not yet change practice; hypothesis-generating for longitudinal effects.
Phenotypic changes in lymphocytes from healthy children with antibody for human T lymphotrophic virus type I (HTLV-I) were studied using two color flow cytometry. The subjects were high school students within a small district of Kyushu, Japan. In the carrier group, a subset of lymphocytes which expressed CD8+CD57+ was significantly lower in percentage (P < 0.01) and in number (P < 0.05). There was no significant difference between carriers and non-carriers in the percentage and number of CD4+Leu8+ cells or CD4+HLA-DR+ cells. The IgG levels were slightly higher in carriers than in non-carriers (P < 0.05). These findings suggest that HTLV-I-infected cells may affect the immune system in healthy carrier children.
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Sato et al. (1993) studied this question.
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