What does this research mean for the field?

High-dose diltiazem alone is as effective as or more effective than moderate-dose propranolol or their combination in improving exercise tolerance, myocardial ischemia, and left ventricular function in patients with stable effort angina. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1983CirculationOpen Access

The effect of diltiazem and propranolol, alone and in combination, on exercise performance and left ventricular function in patients with stable effort angina: a double-blind, randomized, and placebo-controlled study.

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Why the study?

Does diltiazem, propranolol, or their combination improve exercise performance and left ventricular function in patients with stable effort angina compared to placebo?

Structured PICO

Does diltiazem, propranolol, or their combination improve exercise performance and left ventricular function in patients with stable effort angina compared to placebo?

Population

12 patients with stable effort angina

Intervention

Diltiazem 90 mg oral four times daily, propranolol 60 mg oral four times daily, or a combination of 90 mg diltiazem and 60 mg propranolol four times daily, each given for 2-week periods

Comparator

Placebo given for a 2-week period

Outcome

Exercise duration, time to onset of angina pectoris, ischemic ST segment depression, and left ventricular ejection fraction during symptom-limited upright bicycle ergometric exercisesurrogate

High-dose diltiazem alone is as effective or more effective than moderate-dose propranolol or their combination for improving exercise tolerance and LV function in stable angina, while avoiding the adverse effects seen with combination therapy.

Discussion

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Implication

Supports diltiazem or propranolol to improve exercise tolerance in stable angina; confirms calcium-channel blockers as effective beta-blocker alternatives.

Cite This Study

Hung et al. (1983) studied this question.

synapsesocial.com/papers/6a1a1397443d3ecd7cdf532f https://doi.org/10.1161/01.cir.68.3.560

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Implication

Supports diltiazem or propranolol to improve exercise tolerance in stable angina; confirms calcium-channel blockers as effective beta-blocker alternatives.

The effect of diltiazem and propranolol, alone and in combination, on exercise performance and left ventricular function in patients with stable effort angina: a double-blind, randomized, and placebo-controlled study.

Structured PICO

Discussion

Implication

Cite This Study

The effect of diltiazem and propranolol, alone and in combination, on exercise performance and left ventricular function in patients with stable effort angina: a double-blind, randomized, and placebo-controlled study.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider