Key result
Serum 25(OH)D3 levels were significantly associated with the severity of obstructive sleep apnea syndrome in patients with Syndrome Z.
Why the study?
The study was conducted to investigate the association of serum vitamin D levels with the severity of obstructive sleep apnea syndrome in patients with Syndrome Z.
Is serum 25(OH)D3 level associated with the severity of OSAS in patients with metabolic syndrome?
Observational (n=270)
Is serum 25(OH)D3 level associated with the severity of OSAS in patients with metabolic syndrome?
Lower serum vitamin D levels are significantly associated with increased severity of obstructive sleep apnea in patients with metabolic syndrome.
Answers are grounded in this paper and cite their sources.
May support vitamin D screening in severe OSAS with metabolic syndrome; leaves open causality and need for interventional trials.
Background: The interaction of obstructive sleep apnea syndrome (OSAS) with metabolic syndrome (MetS) is known as syndrome Z. The aim of this study was to investigate the association of serum vitamin D levels with severity of OSAS in patients with Syndrome Z. Methods: In this retrospective study, 270 patients with MetS and OSAS were included. Demographic data, lifestyle habits, anthropometric measurements, sleep characteristics, polysomnographic indices, and laboratory results were recorded from the patient files. Multivariable logistic regression analyses were performed to determine the associations of serum 25(OH)D3 levels with OSAS. Results: Of the 270 patients, 71.9% were female. The mean age was 46.86 ± 8.46 (33–72) years. Of the participants, 8.2% did not have OSAS (control group), while 30.4% had mild, 28.1% had moderate, and 33.3% had severe OSAS. There were significant differences in gender, waist circumference, hip circumference, waist/hip ratio, neck circumference, body mass index, apnea–hypopnea index, total sleep time, average SpO2 and Epworth sleepiness scale score, oxygen desaturation index, blood glucose, total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and 25(OH)D3 levels. There was a significant difference in serum 25(OH)D3 level with increasing severities of OSAS (none+mild to moderate+severe OSAS). After adjusting for potential confounding factors in multivariable logistic regression analyses, we found that serum 25(OH)D3 level was significantly associated with the severity of OSAS. Conclusions: Serum 25(OH)D3 level was significantly associated with the severity of OSAS in patients with Syndrome Z. Therefore, patients with MetS and OSAS should be investigated for the presence of vitamin D insufficiency and, if observed, referred for vitamin D treatment.
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Kilavuz et al. (2021) conducted an observational in Syndrome Z (Metabolic Syndrome and Obstructive Sleep Apnea Syndrome) (n=270). Serum 25(OH)D3 levels was evaluated on Association of serum 25(OH)D3 levels with OSAS severity. Serum 25(OH)D3 levels were significantly associated with the severity of obstructive sleep apnea syndrome in patients with Syndrome Z.
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