Population
Rat neonatal H9c2 and primary adult rabbit left ventricular cardiomyocytes
Comparison
Angiotensin1-9 (Ang1-9) vs Control, AngII alone, vasopressin alone, and…
Design
Preclinical
Authors
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Ang1-9 may limit AngII-driven cardiomyocyte hypertrophy via AT2R; leaves open therapeutic translation pending in vivo and clinical studies.
Ang1-9 directly antagonizes pro-hypertrophic signaling in cardiomyocytes via the angiotensin type 2 receptor, identifying a novel biological role and potential therapeutic target in cardiovascular disease.
Flores‐Muñoz et al. (2010) studied this question.
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