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OBJECTIVE: Treatment adherence impact (TAI) is the quantification of the effects of adherence behaviors on medical or psychological outcomes using systematic assessment and analytic methods. The purpose of this review is to provide a framework for the measurement and analysis of TAI. METHODS: Specific studies were selected from the treatment adherence literature to illustrate methods to assess TAI. RESULTS: There are many methods available to investigators to evaluate TAI and, when possible, multiple impact outcomes should be included in adherence studies. The methods available to assess TAI and barriers to assessing TAI vary across illness group requiring illness-specific applications of the concepts presented. CONCLUSIONS: Systematically examining TAI in adherence studies could advance the state of the art of treatment adherence science.
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Pai et al. (2009) studied this question.
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