Key result
High-dose ulinastatin during CPB is linked to improved oxygenation and reduced lung injury.
Why the study?
Does high-dose ulinastatin improve postoperative pulmonary oxygenation in patients undergoing aortic valve surgery with cardiopulmonary bypass?
Population
94 patients who underwent aortic valve repair or replacement with moderate hypothermic cardiopulmonary…
Comparison
Ulinastatin 10,000 U/kg administered… vs No ulinastatin administered during CPB (Group C).
Design
Cohort
Follow-up
Up to 12 hours after ICU arrival
Authors
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Ulinastatin during CPB was associated with better early oxygenation; hypothesis-generating and should not change practice without RCTs.
Cohort (n=94)
No
Does high-dose ulinastatin improve postoperative pulmonary oxygenation in patients undergoing aortic valve surgery with cardiopulmonary bypass?
p-value: p=<0.001
High-dose ulinastatin administered during cardiopulmonary bypass significantly improves early postoperative pulmonary oxygenation in patients undergoing aortic valve surgery, though it does not shorten the duration of mechanical ventilation.
Rhee et al. (2018) conducted a cohort in Aortic valve surgery with moderate hypothermic cardiopulmonary bypass (n=94). High-dose ulinastatin vs. No ulinastatin was evaluated on PaO2/FiO2 ratio 2 hours after weaning from cardiopulmonary bypass (p=<0.001). High-dose ulinastatin administered during cardiopulmonary bypass significantly improved the postoperative PaO2/FiO2 ratio and reduced the incidence of lung injury compared to no ulinastatin.