Key result
High-dose ulinastatin during CPB is linked to improved oxygenation and reduced lung injury.
Why the study?
Does high-dose ulinastatin improve postoperative pulmonary oxygenation in patients undergoing aortic valve surgery with cardiopulmonary bypass?
Cohort (n=94)
No
Does high-dose ulinastatin improve postoperative pulmonary oxygenation in patients undergoing aortic valve surgery with cardiopulmonary bypass?
p-value: p=<0.001
High-dose ulinastatin administered during cardiopulmonary bypass significantly improves early postoperative pulmonary oxygenation in patients undergoing aortic valve surgery, though it does not shorten the duration of mechanical ventilation.
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Ulinastatin during CPB was associated with better early oxygenation; hypothesis-generating and should not change practice without RCTs.
Rhee et al. (2018) conducted a cohort in Aortic valve surgery with moderate hypothermic cardiopulmonary bypass (n=94). High-dose ulinastatin vs. No ulinastatin was evaluated on PaO2/FiO2 ratio 2 hours after weaning from cardiopulmonary bypass (p=<0.001). High-dose ulinastatin administered during cardiopulmonary bypass significantly improved the postoperative PaO2/FiO2 ratio and reduced the incidence of lung injury compared to no ulinastatin.
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