Key result
Baseline frailty was associated with a higher incidence of postoperative delirium compared to nonfrail patients after cardiac surgery (48% vs 13%; adjusted OR 6.31; 95% CI 1.18-33.74; P=0.03).
Why the study?
The cognitive consequences of frailty after cardiac surgery have not been well described.
Does baseline frailty increase the risk of postoperative delirium and cognitive decline in patients undergoing cardiac surgery?
Population
133 cardiac surgery patients with baseline frailty assessments
Comparison
Prefrail and frail patients vs nonfrail patients
Design
Prospective observational study nested in 2 trials
Follow-up
1 year
Authors
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May support frailty screening for delirium risk stratification after cardiac surgery; hypothesis-generating and requires prospective validation.
Observational (n=133)
Does baseline frailty increase the risk of postoperative delirium and cognitive decline in patients undergoing cardiac surgery?
Effect estimate: adjusted OR 6.31 (95% CI 1.18-33.74)
Absolute Event Rate: 48% vs 13%
p-value: p=0.03
Baseline frailty and prefrailty are strongly associated with an increased risk of postoperative delirium and early cognitive decline following cardiac surgery.
Nomura et al. (2018) conducted an observational in cardiac surgery (n=133). Baseline frailty vs. Nonfrail was evaluated on postoperative delirium during hospitalization (adjusted OR 6.31, 95% CI 1.18-33.74, p=0.03). Baseline frailty was associated with a higher incidence of postoperative delirium compared to nonfrail patients after cardiac surgery (48% vs 13%; adjusted OR 6.31; 95% CI 1.18-33.74; P=0.03).
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