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Impaired glucose tolerance and type 2 diabetes are associated with significantly increased vascular inflammation in carotid atherosclerosis, as detected by FDG-PET, compared to normal glucose tolerance. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 9, 2010Circulation Cardiovascular Imaging

Vascular Inflammation in Patients With Impaired Glucose Tolerance and Type 2 Diabetes

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Population

90 age- and sex-matched subjects with different glucose tolerance

Comparison

Impaired glucose tolerance and Type 2 diabetes… vs Age- and sex-matched control subjects with…

Design

Cross-sectional

Authors

TKTae Nyun KimInje University SKSungeun KimIncheon Medical Center SYSae Jeong YangSeoul St. Mary's Hospital

Discussion

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Implication

FDG-PET TBR may detect early carotid inflammation in IGT/T2DM before IMT changes; hypothesis-generating and should not yet change practice.

Structured PICO

Population

90 age- and sex-matched subjects with different glucose tolerance (30 normal glucose tolerance subjects, 30 impaired glucose tolerance subjects, and 30 T2DM subjects)

Intervention

Impaired glucose tolerance and Type 2 diabetes mellitus (exposure)

Comparator

Age- and sex-matched control subjects with normal glucose tolerance

Outcome

Vascular inflammation measured as mean and maximum blood-normalized standardized uptake value (target-to-background ratio [TBR]) using 18F-FDG PETsurrogate

Impaired glucose tolerance and T2DM are associated with increased vascular inflammation in carotid atherosclerosis as detected by FDG-PET, which may precede structural changes like intima-media thickening.

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Kim et al. (2010) studied this question.

synapsesocial.com/papers/6a1a2cf3db849bfdc47fca01 https://doi.org/10.1161/circimaging.109.888909

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Implication

FDG-PET TBR may detect early carotid inflammation in IGT/T2DM before IMT changes; hypothesis-generating and should not yet change practice.

Vascular Inflammation in Patients With Impaired Glucose Tolerance and Type 2 Diabetes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Vascular Inflammation in Patients With Impaired Glucose Tolerance and Type 2 Diabetes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider