Why the study?
Does greater baseline epicardial fat volume index predict the development of non-calcified coronary plaque in asymptomatic individuals?
Does greater baseline epicardial fat volume index predict the development of non-calcified coronary plaque in asymptomatic individuals?
Greater baseline epicardial fat volume independently predicts the development of non-calcified coronary plaque in asymptomatic individuals, suggesting its utility for cardiovascular risk stratification.
Greater epicardial fat volume may be associated with incident non-calcified plaque; hypothesis-generating for risk stratification and requires prospective validation.
AIM: Epicardial adipose tissue (EAT) has been suggested as a contributing factor for coronary atherosclerosis based on the previous cross-sectional studies and pathophysiologic background. However, a causal relationship between EAT and the development of non-calcified coronary plaque (NCP) has not been investigated. METHODS: ) was assessed in relation to the development of NCP on the follow-up CT where the results were classified into "calcified plaque (CP)," "no plaque," and "NCP" groups. RESULTS: ; P=0.021). Multivariable logistic regression analysis demonstrated that the presence of diabetes (OR, 9.081; 95% CI, 1.682-49.034; P=0.010) and the 3rd tertile of EFVi (OR, 4.297; 95% CI, 1.040-17.757; P=0.044 compared to the 1st tertile) were the significant predictors for the development of NCP on follow-up CT. CONCLUSIONS: Greater amount of EAT at baseline CT independently predicts the development of NCP in asymptomatic individuals.
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Hwang et al. (2016) studied this question.
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