What does this research mean for the field?

Hyperthyroidism accelerates the deterioration of anaerobic cardiac performance by inhibiting phosphofructokinase (PFK) in the particulate fraction, which reduces anaerobic glycolysis and decreases ATP levels. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1969Journal of Clinical InvestigationOpen Access

Anaerobic performance and metabolism of the hyperthyroid heart

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Why the study?

Does experimentally induced hyperthyroidism affect anaerobic performance and metabolism in rat hearts?

Population

Anaerobically perfused hearts from rats with experimentally induced hyperthyroidism

Design

Preclinical

Follow-up

30 min

Authors

RARuth A. AltschuldUniversity of Maryland, Baltimore AWAlan N. WeissCedars-Sinai Medical Center FKFred A. KrugerBelfast City Council

Discussion

Member takes

Implication

Hyperthyroidism may impair cardiac anaerobic metabolism in experimental models; hypothesis-generating for human relevance.

Structured PICO

Does experimentally induced hyperthyroidism affect anaerobic performance and metabolism in rat hearts?

Population

Anaerobically perfused hearts from rats with experimentally induced hyperthyroidism

Intervention

Anoxic perfusion (30 min)

Outcome

Pacemaker activity and ventricular performancesurrogate

Hyperthyroidism impairs anaerobic performance and glycolysis in rat hearts, likely due to phosphofructokinase inhibition in the particulate fraction.

Cite This Study

Altschuld et al. (1969) studied this question.

synapsesocial.com/papers/6a1a2f039b2d28adb7b4fa3c https://doi.org/10.1172/jci106157

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Anaerobic performance and metabolism of the hyperthyroid heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Anaerobic performance and metabolism of the hyperthyroid heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider