Why the study?
Conventional osteosarcomas are generally resistant to radiation therapy, making surgery and chemotherapy the primary modalities, but demonstrating the efficacy of combined treatment in rare aggressive tumors remains important.
Combined treatment with preoperative chemotherapy and R0 resection can achieve complete clinical response in femoral osteosarcoma.
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Supports combined preoperative chemotherapy and R0 resection in femoral osteosarcoma; hypothesis-generating and requires prospective validation before practice change.
Osteosarcomas are rare tumors with aggressive biology. It is important to refer such patients to a high-volume center, where an accurate diagnosis and optimal treatment are more likely to be performed. In contrast to Ewing's sarcoma, conventional osteosarcomas are believed to be generally resistant to radiation therapy, and the main treatment modalities are surgery and chemotherapy. In this clinical case, we demonstrate the efficacy of combined treatment of osteosarcoma of the femur.Preoperative chemotherapy allowed to evaluate tumor sensitivity to systemic treatment in vivo and optimize adjuvant treatment after R0 resection which allowed to achieve complete clinical response to treatment.
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Filimonov et al. (2022) studied this question.
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