De novo synthesize of bile acids in pulmonary arterial hypertension lung

Q: What does this research mean for the field?

De novo bile acid synthesis, driven by increased CYP7B1 expression in pulmonary vascular endothelial cells, is highly elevated in the pulmonary arterial hypertension (PAH) lung and represents a novel pathogenic mechanism. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

Yidan Zhao; Hana Yun; Jenny Peng; Li Yin; Lei Chu; Licun Wu; Ryan D. Michalek; Mingyao Liu; Shaf Keshavjee; Thomas K. Waddell; John Granton; Marc de Perrot

doi:10.1007/s11306-014-0653-y

April 10, 2014MetabolomicsOpen Access

De novo synthesize of bile acids in pulmonary arterial hypertension lung

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Structured PICO

P

Population

16 human lung tissue samples: 8 from end-stage pulmonary arterial hypertension (PAH) patients undergoing lung transplantation (mean age 40 ± 12 years, 5 females) and 8 normal control samples from cancer patients undergoing lobectomy (mean age 47 ± 15 years, 4 females).

I

Intervention

Untargeted metabolic profiling using liquid/gas chromatography coupled to mass spectrometry (LC/GC-MS), transcriptomic analysis, and immunoblotting

C

Comparator

Normal lung tissue from cancer patients undergoing lobectomy

O

Outcome

Levels of bile acid metabolites and expression of CYP7B1 gene and proteinsurrogate

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Implication

De novo synthesis of bile acids via CYP7B1 is upregulated in PAH lungs, suggesting a novel metabolic pathway involved in the pathogenesis of pulmonary arterial hypertension.

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Cite This Study

Zhao et al. (2014) studied this question.

synapsesocial.com/papers/6a1a413555a14a6e4b3c2440 https://doi.org/10.1007/s11306-014-0653-y

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De novo synthesize of bile acids in pulmonary arterial hypertension lung

Structured PICO

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Implication

Abstract

Discussion

Cite This Study

De novo synthesize of bile acids in pulmonary arterial hypertension lung

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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