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December 15, 1993BloodOpen Access

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

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GWGuo‐Liang WangGuizhou Provincial People's HospitalGSGL SemenzaJohns Hopkins University

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Wang et al. (1993) studied this question.

synapsesocial.com/papers/6a1a550b91ebb306cd351074https://doi.org/10.1182/blood.v82.12.3610.3610
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.1993 · 865 citations
  2. 2A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.1992 · 2,447 citations
  3. 3A 24-base-pair sequence 3' to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer.1993 · 131 citations
  4. 4Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.1991 · 1,006 citations
  5. 5Physiologic regulation and tissue localization of renal erythropoietin messenger RNA1987 · 15 citations