Why the study?
Nuclear factor kappa B assumes a crucial role in diabetic cardiomyopathy, but its precise role remains a subject of ongoing investigation.
This review highlights the crucial role of the pleiotropic transcription factor NF-κB in the pathophysiology of diabetic cardiomyopathy.
No immediate change to diabetic cardiomyopathy management; extends NF-κB pathway insights for future mechanistic and therapeutic research.
Diabetic cardiomyopathy (DCM), a major risk factor contributing to diabetes-related morbidity and mortality, manifests as a pathophysiologic condition in humans independently of coronary artery disease or hypertension. Several transcription factors intricately participate in the initiation and progression of associated processes. Among these, nuclear factor kappa B (NF-κB), a pleiotropic transcription factor, assumes a crucial role in regulating oxidative stress, inflammatory response, endothelial dysfunction, myocardial fibrosis and hypertrophy, and cardiomyocyte apoptosis in DCM. However, the precise role of NF-κB in DCM remains a subject of ongoing investigation. This article provides a comprehensive review of NF-κB's involvement in several processes associated with DCM.
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Liu et al. (2024) studied this question.
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