Adaptive response of breastmilk metabotype and miRNAs patterns in a rat model of gestational diabetes and its postpartum evolution

Paul Bobin; Sandrine Le Guillou; Mathilde Gourdel; Chloé Cloteau; Johann Laubier; Khadija El Moumen; Agnès David-Sochard; Alexis Gandon; Bertrand Kaeffer; Madia Charlier; Dominique Darmaun; Gwenola Le Dréan; Marie Cécile Alexandre-Gouabau

doi:10.1016/j.jnutbio.2026.110421

May 1, 2026The Journal of Nutritional BiochemistryOpen Access

Adaptive response of breastmilk metabotype and miRNAs patterns in a rat model of gestational diabetes and its postpartum evolution

View Full Paper

Ask AI

Bookmark

Share

Key Points

The study aims to explore how gestational diabetes affects breastmilk composition postpartum, focusing on metabolites and miRNAs.
Utilized a rat model of gestational diabetes to compare breastmilk from resolved vs persistent impaired glucose tolerance (IGT).
Analyzed milk samples for insulin regulators, plasmalogens, ceramides, glutathione precursors, and miRNAs post-delivery.
Resolved IGT-colostrum showed higher levels of insulin regulators than persistent IGT-colostrum.
Higher concentrations of plasmalogen and C24:1-ceramide were found in resolved IGT-colostrum compared to persistent IGT-colostrum.
Resolved IGT-milk was enriched in glutathione precursors and insulin-signalling miRNAs than persistent IGT-milk.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Investigates breastmilk composition changes in gestational diabetes, suggesting implications for maternal health.

Abstract

• Maternal postpartum IGT resolution yields a distinct milk metabotype vs persistent IGT. • Resolved IGT-colostrum is richer in insulin regulators vs persistent IGT-colostrum. • Resolved IGT-colostrum has higher plasmalogen and C24:1-ceramide vs persistent IGT-colostrum. • Resolved IGT-milk has more glutathione precursors vs persistent IGT-milk. • Resolved IGT-milk is enriched in insulin-signalling miRNAs vs persistent IGT-milk.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Bobin et al. (2026) studied this question.

synapsesocial.com/papers/6a1a7e9c0307b7850943134c https://doi.org/10.1016/j.jnutbio.2026.110421

View Full Paper

Ask AI

Bookmark

Share

Adaptive response of breastmilk metabotype and miRNAs patterns in a rat model of gestational diabetes and its postpartum evolution

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Adaptive response of breastmilk metabotype and miRNAs patterns in a rat model of gestational diabetes and its postpartum evolution

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading