Phase III Trial of EpiWatch for Tonic-Clonic Seizure Detection in Children and Adults

Risks of sudden unexpected death in epilepsy are high in individuals with uncontrolled tonic-clonic seizures (TCSs), particularly in those who sleep alone. Wearable seizure detection devices can alert caregivers to provide timely intervention; however, current devices risk stigma and have high false alarm rates (FARs) that discourage consistent use and caregiver responses. EpiWatch is a seizure detection application (app) developed for the Apple Watch, designed to minimize FAR without compromising detection sensitivity or latency. We evaluated the sensitivity and FAR of EpiWatch for detecting TCSs in children and adults undergoing video-EEG monitoring.