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May 27, 2026Open Access

Striatal Spinophilin Enhances the D2 Receptor Interactome to Mediate D2 Receptor Agonist-Induces Locomotor Suppression

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Key Points

This research aims to investigate the role of striatal spinophilin in enhancing the D2 receptor interactome and its effects on locomotor behavior.
Used animal models to explore the interactions between spinophilin and D2 receptors.
Administered D2 receptor agonists to assess their effects on locomotion.
Analyzed receptor signaling pathways associated with locomotor suppression.
Spinophilin increased D2 receptor interactions during agonist administration, enhancing locomotor suppression.
Locomotor activity was significantly reduced following D2 receptor agonist treatment, indicating strong agonist efficacy.

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Implication

Shows D2 receptor agonist-induced locomotor suppression in mice, suggesting a role for spinophilin in receptor interactions.

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Cite This Study

Basant Hens (2026) studied this question.

synapsesocial.com/papers/6a1a7ecb0307b785094315e5 https://doi.org/10.7912/xxys-ww77

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