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Identifies NFKBIA and PECAM1 as significant biomarkers for neonatal necrotizing enterocolitis, suggesting a novel diagnostic framework.
BACKGROUND: Necrotizing enterocolitis (NEC), a life-threatening neonatal gastrointestinal disease, lacks reliable biomarkers. This study explores PANoptosis-a novel inflammatory cell death pathway-in NEC pathogenesis. MATERIALS AND METHODS: ROC, calibration, and decision curve analyses. RESULTS: Fifty-five NEC-associated PANoptosis genes were identified, primarily enriched in inflammatory pathways. NFKBIA and PECAM1 emerged as pivotal biomarkers. The model achieved an AUC and C-index of 0.903, with calibration curves confirming reliability. DCA and clinical impact curves demonstrated significant clinical utility. CONCLUSION: NFKBIA and PECAM1 are promising biomarkers for surgical NEC linked to PANoptosis. This study establishes a diagnostic framework and proposes therapeutic targets for advanced NEC management.
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Jia et al. (2026) studied this question.
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