Long-Term Potentiation of Hippocampal Synaptic Transmission Affects Rate of Behavioral Learning

Electrical stimulation techniques were used to produce a long-lasting potentiation of synaptic transmission in the hippocampus of naïve rabbits. Animals were then classically conditioned. Long-term potentiation of the hippocampus before training increased the rate at which animals subsequently learned the conditioning task. This result has significance for potential cellular mechanisms of associative learning.