Key result
Higher gut microbiota dietary scores correlate with ~12% lower CV mortality per unit in CKM patients.
Why the study?
The link between the dietary index for gut microbiota and mortality risk in the cardiovascular-kidney-metabolic syndrome population remains unclear.
Does a higher dietary index for gut microbiota (DI-GM) reduce all-cause and cardiovascular mortality in patients with Cardiovascular-Kidney-Metabolic (CKM) Syndrome?
Cohort (n=13,562)
Does a higher dietary index for gut microbiota (DI-GM) reduce all-cause and cardiovascular mortality in patients with Cardiovascular-Kidney-Metabolic (CKM) Syndrome?
Higher dietary index for gut microbiota is associated with significantly reduced all-cause and cardiovascular mortality in patients with Cardiovascular-Kidney-Metabolic Syndrome.
Answers are grounded in this paper and cite their sources.
Supports lower mortality with higher DI-GM in CKM syndrome; hypothesis-generating pending prospective trials.
The link between the dietary index for gut microbiota (DI‐GM) and the risk of death in the Cardiovascular‐Kidney‐Metabolic Syndrome (CKM) population remains unclear. Our research investigates the relationship between DI‐GM and mortality in CKM patients. Data from 13,562 individuals diagnosed with CKM, obtained from the National Health and Nutrition Examination Survey (NHANES) spanning 2007 to 2018, were analyzed. Kaplan–Meier curves, Cox regression, smooth curve fitting, and Subgroup analyses were applied to assess the link between DI‐GM and mortality. During the average 82‐months follow‐up period, a total of 1236 deaths occurred, including 371 cases of cardiovascular death. Kaplan–Meier analysis showed that the lowest DI‐GM group exhibited the highest rates of mortality. Multivariable Cox regression found that a one‐point increase in the DI‐GM score was associated with a 10% reduction in all‐cause mortality risk and a 12% decrease in cardiovascular mortality risk. Smooth curve fitting and continuous dose–response estimates indicated a negative linear relationship between DI‐GM scores and both all‐cause and cardiovascular mortality, consistent across various subgroups. This research reveals that higher DI‐GM concentrations in CKM syndrome patients correlate strongly with improved survival outcomes, especially for all‐cause mortality and cardiovascular death among patients in CKM stages 0–3, while also showing significant benefits for all‐cause mortality among patients in CKM stage 4.
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Huang et al. (2026) conducted a cohort in Cardiovascular-Kidney-Metabolic Syndrome (CKM) (n=13,562). Dietary index for gut microbiota (DI-GM) vs. Lower DI-GM scores was evaluated on All-cause and cardiovascular mortality (10% reduction (all-cause), 12% reduction (CV)). A one-point increase in the dietary index for gut microbiota score in CKM patients was associated with a 10% reduction in all-cause mortality risk and a 12% decrease in cardiovascular mortality.
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