Comparing the rates of hypersensitivity reactions in patients undergoing first-dose taxanes utilizing fixed-rate vs. stepwise-titration infusions.

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Key Points

This study aims to determine if a titrated infusion protocol reduces the incidence of first-dose hypersensitivity reactions to taxanes.
Retrospective cohort study conducted at a single hematology/oncology infusion center.
Patients in the fixed-rate arm received a consistent infusion rate; titration arm utilized a three-step protocol.
Primary endpoint assessed was the rate of immediate hypersensitivity reactions during the first dose of docetaxel or paclitaxel.
Hypersensitivity reactions occurred in 7.1% of the fixed-rate group and 11.3% of the titration group (OR 1.67, 95% CI 0.89-3.15; p=0.1104).
No differences observed in the severity of hypersensitivity reactions or treatment discontinuation rates between groups.
Secondary endpoints indicated a similar rate of immediate HSRs with the first or second dose combined at 5.5% and 8.2%, respectively.

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Retrospective cohort study evaluates infusion protocols for first-dose taxanes, suggesting no significant benefits of titration.

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Valdes et al. (2026) studied this question.

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