Synthesis of 3‑Spirocyclobutyl Oxindoles via N-Heterocyclic Carbene-Catalyzed Radical Alkylarylation of Bicyclo[1.1.0]butanes

Xian Li; Jianquan Zhu; Yu Liang; Chenxia Yu; Tuanjie Li; Changsheng Yao; Kai Zhang

doi:10.1039/d6cc01634k

January 1, 2026Chemical Communications

Synthesis of 3‑Spirocyclobutyl Oxindoles via N-Heterocyclic Carbene-Catalyzed Radical Alkylarylation of Bicyclo[1.1.0]butanes

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Key Points

The aim is to efficiently synthesize 3-spirocyclobutyl oxindoles using N-Heterocyclic Carbene-catalyzed methods.
Employs N-Heterocyclic Carbene (NHC) catalysis.
Utilizes radical alkylarylation techniques.
Focuses on Bicyclo[1.1.0]butanes (BCBs) as the starting materials.
Successfully synthesized a range of 3-spirocyclobutyl oxindoles.
Demonstrated the viability of this reaction pathway in producing bioactive heterocycles.
Indicated significant efficiency in the reaction conditions employed.

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Implication

Demonstrates effective synthesis of spirocyclobutyl oxindoles using NHC-catalyzed methods, highlighting new avenues in organic chemistry.

Abstract

3-Spirocyclobutyl oxindoles and their derivatives represent a class of highly significant bioactive heterocycles in organic chemistry. Herein, an N-Heterocyclic Carbene(NHC)-catalyzed radical alkylarylation of Bicyclo[1.1.0]butanes (BCBs) for the convenient construction of...

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Li et al. (2026) studied this question.

synapsesocial.com/papers/6a1a80c00307b78509432ace https://doi.org/10.1039/d6cc01634k

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Synthesis of 3‑Spirocyclobutyl Oxindoles via N-Heterocyclic Carbene-Catalyzed Radical Alkylarylation of Bicyclo[1.1.0]butanes

Key Points

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Implication

Abstract

Discussion

Cite This Study

Synthesis of 3‑Spirocyclobutyl Oxindoles via N-Heterocyclic Carbene-Catalyzed Radical Alkylarylation of Bicyclo[1.1.0]butanes

Key Points

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Implication

Abstract

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Cite This Study

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