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This research aims to develop an efficient method for the enantioselective synthesis of 3-hydroxy-3-substituted oxindoles using NHC catalysis.

Enantioselective Synthesis of 3‐Hydroxy Oxindoles via NHC ‐Catalyzed 2 + 2 Cycloaddition

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Randomized trial demonstrates efficient synthesis of 3-hydroxy oxindoles, highlighting their utility as chiral building blocks.

This research aims to develop an efficient method for the enantioselective synthesis of 3-hydroxy-3-substituted oxindoles using NHC catalysis.
NHC-catalyzed [2 + 2] cycloaddition/ring-opening sequence
Use of diverse substrates
Characterization of key intermediates by HRMS and NMR
Products obtained in 84% isolated yield with 96:4 enantiomeric ratio (er) and >20:1 diastereomeric ratio (dr).
Broad substrate scope with generally moderate to excellent yields.
Products maintained stereoselectivity during further derivatizations.

Liu et al. (2026) studied this question.

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