Catalytic Asymmetric Synthesis of 3-Hydroxyindolenines Using Achiral Oxaziridines

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Catalytic synthesis achieved enantioselectivity in 3-hydroxyindolenines from substrates, implying new methods for indole alkaloids.

The synthesis achieved high enantioselectivity in 3-hydroxyindolenines using racemic oxaziridines.
Products were utilized in the total synthesis of indole alkaloids like hinckdentine A, enhancing their potential.
Analysis employed DFT calculations to understand coordination geometry and reaction pathways in substrate interactions.
This method showcases potential for further reagent development through kinetic resolution of oxaziridines.

Pang et al. (2025) studied this question.

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