Engineering Supramolecular Metal–Organic Frameworks for Stable and Efficient Perovskite Quantum Dots by Defect Passivation and Heterostructure Construction

@γ-CD-MOFs achieves high photoluminescence quantum yield (73%) alongside exceptional thermal, photochemical, and environmental stabilities. Mechanistic investigations reveal synergistic augmentation effects: multianchored defect passivation via γ-CD hydroxyl groups, enhanced radiative recombination through type-I heterojunction-driven directional carrier injection, and suppression of ion migration and phase separation by MOFs' physical barriers and interfacial chemical bonds. The composite was successfully applied in white light-emitting diodes, boasting color rendering index of 90.1 and color gamut coverage of 115%. Furthermore, benefiting from the good biocompatibility imparted by γ-CD-MOFs, the composite serves as fluorescent probe for specific labeling and imaging of lysosomes in living cells. This supramolecular-MOFs strategy provides design principles for developing stable, efficient, and biologically compatible PQDs, accelerating their optoelectronic and bioimaging applications.