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May 30, 2026Journal of Clinical Oncology

Proton or photon? Comparative survival and toxicity outcomes in lung cancer radiotherapy: A systematic review and meta-analysis.

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Authors

RPRoshan Mustafa PathanJSJugraj SinghNTNabiha Tabassum

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Overview

Systematic review compares proton and photon radiotherapy outcomes in lung cancer, suggesting targeted use of protons.

Key Points

  • To compare survival and toxicity outcomes between proton and photon radiotherapy in non-small cell lung cancer.
  • Systematic search of Pubmed, MEDLINE, and Embase for observational studies comparing proton and photon RT.
  • Random-effects meta-analysis to pool risk and hazard ratios for toxicity and overall survival outcomes.
  • Included a total of 7 observational studies with 246,267 individuals.
  • Pooled analysis shows proton RT demonstrated a non-significant trend favoring overall survival (HR 0.79, 95% CI 0.51-1.23; P=0.29).
  • No significant overall survival benefit observed for Stage I NSCLC treated with SBRT (HR 0.70, 95% CI 0.32-1.55; P=0.38).
  • Proton RT showed significantly less toxicity in centrally located early-stage NSCLC (RR 0.32, 95% CI 0.14-0.74; P=0.008).

Cite This Study

Pathan et al. (2026) studied this question.

synapsesocial.com/papers/6a1a81100307b78509432e86https://doi.org/10.1200/jco.2026.44.16_suppl.e20048
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