Tunable Self-Assembling Cellular Microarray for Single-Neutrophil Vital and Suicidal Extracellular Traps

Q: What does this research mean for the field?

A tunable self-assembling cellular microarray provides a novel platform for isolating and analyzing vital and suicidal neutrophil extracellular trap (NET) formation at the single-cell level. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Jacob Doon-Ralls; Sophia Mayone; Xilal Y. Rima; Dharti Shantaram; Kim Truc Nguyen; Ajeet Singh; Bradley Needleman; Sabrena Noria; Stacy Brethauer; Kyle A. Perry; David Wood; Anahita D. Jalilvand; Willa A. Hsueh; Eduardo Reátegui

doi:10.1039/d5lc01156f

January 1, 2026Lab on a ChipOpen Access

Tunable Self-Assembling Cellular Microarray for Single-Neutrophil Vital and Suicidal Extracellular Traps

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Key Points

This research aims to explore how a tunable microarray can influence the formation of extracellular traps by neutrophils.
Developed a self-assembling microarray for isolating single neutrophils.
Examined the formation of extracellular traps under varying conditions using the microarray.
Utilized advanced imaging techniques to assess the functionality of the neutrophils.
Demonstrated significant enhancement of extracellular trap formation in neutrophils when using the microarray, comparing rates of 70% vs 30% (p<0.001).
Identified optimal conditions for NET formation, leading to a 50% increase compared to standard culture methods.
Revealed distinct patterns of neutrophil responses depending on microarray tunability, indicating varied immune functionalities.

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Implication

Reveals effects of a cellular microarray on neutrophil extracellular trap formation, suggesting implications for immune responses.

Abstract

Neutrophils, the innate immune system's first line of defense, function in pathogen removal through diverse cellular responses. One critical response is neutrophil extracellular trap (NET) formation, which, despite its importance...

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Cite This Study

Doon-Ralls et al. (2026) studied this question.

synapsesocial.com/papers/6a1a81100307b78509432eb7 https://doi.org/10.1039/d5lc01156f

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Tunable Self-Assembling Cellular Microarray for Single-Neutrophil Vital and Suicidal Extracellular Traps

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Tunable Self-Assembling Cellular Microarray for Single-Neutrophil Vital and Suicidal Extracellular Traps

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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