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Shows the importance of Brat protein's RNA-binding in larvae, highlighting its role in mRNA regulation.
alleles and recapitulated characteristic abdominal segmentation defects. Finally, RT-qPCR showed increased expression of endogenous Brat target mRNAs in mutant larvae, consistent with loss of Brat-mediated repression. Together, these results demonstrate that direct RNA binding is an essential molecular activity of Brat and that post-transcriptional regulation of Brat target mRNAs underlies its critical roles across development.
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Connacher et al. (2026) studied this question.
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