Solvent and Catalyst-Free Mechanochemical Synthesis of Indenyl-Derived Thiazolone imine, Thiazolidin-4-one and Thiazolidin-4-ol Hybrids: Anticancer Evaluation and Molecular Modeling Studies

Sanket Shantaram Mohite; Vikas M. Bangade; Ambareen Shaikh; Bhushan Bhagwantrao Popatkar

doi:10.1039/d6md00178e

January 1, 2026RSC Medicinal Chemistry

Solvent and Catalyst-Free Mechanochemical Synthesis of Indenyl-Derived Thiazolone imine, Thiazolidin-4-one and Thiazolidin-4-ol Hybrids: Anticancer Evaluation and Molecular Modeling Studies

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Key Points

The study aims to explore the potential of indenyl-derived thiazole derivatives in developing new cancer medications.
Utilized a mechanochemical synthesis approach without solvents or catalysts.
Examined the anticancer properties of thiazolone and thiazolidin hybrids through laboratory evaluations.
Conducted molecular modeling studies to assess compound interactions.
Demonstrated significant anticancer activity of thiazolone and thiazolidin-4-one hybrids with specific efficacy rates.
Identified promising structural features for therapeutic enhancement in cancer treatment.

Implication

Evaluates anticancer effects of thiazolone hybrids in cancer therapy, suggesting innovative therapeutic approaches.

Abstract

To shed light on the significance of indenyl-derived thiazole derivatives in the advancement of cancer medication and to contribute to therapeutic innovation, we wish to disclose a facile, effective and...

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Cite This Study

Mohite et al. (2026) studied this question.

synapsesocial.com/papers/6a1a81100307b78509432f4e https://doi.org/10.1039/d6md00178e

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Solvent and Catalyst-Free Mechanochemical Synthesis of Indenyl-Derived Thiazolone imine, Thiazolidin-4-one and Thiazolidin-4-ol Hybrids: Anticancer Evaluation and Molecular Modeling Studies

Key Points

Implication

Abstract

Discussion

Cite This Study

Solvent and Catalyst-Free Mechanochemical Synthesis of Indenyl-Derived Thiazolone imine, Thiazolidin-4-one and Thiazolidin-4-ol Hybrids: Anticancer Evaluation and Molecular Modeling Studies

Key Points

Implication

Abstract

Discussion

Cite This Study

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