What does this research mean for the field?

People with cystic fibrosis exhibit weaker physiological acclimatization to heat compared to healthy controls, characterized by less profound reductions in systolic blood pressure and serum glucose, and less responsive urine concentration capacity. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to evaluate the impact of personal temperature exposure on physiological parameters in individuals with cystic fibrosis compared to healthy controls.

May 30, 2026Scientific Reports0 citationsOpen Access

Associations of personal temperature exposure in the preceding days with vital signs, biochemical, and hydration parameters in cystic fibrosis

PAPinelopi AnagnostopoulouUniversity of Cyprus PKPanayiotis KouisUniversity of Cyprus KPKaterina PantavouAgricultural University of Athens

Key Points

This study aims to evaluate the impact of personal temperature exposure on physiological parameters in individuals with cystic fibrosis compared to healthy controls.
Prospective case-control design involving individuals with cystic fibrosis and family controls, using wearable sensors to measure temperature exposure and physical activity over three two-week periods.
Assessment of vital signs, pulmonary function, biochemical parameters, and hydration status after each temperature exposure period.
Comparison of temperature exposure effects on systolic blood pressure, serum glucose, and urine osmolality between groups.
In controls, higher temperature exposure correlated with lower systolic blood pressure (−2.42 vs. −1.53 mmHg) and serum glucose (−5.01 vs. −3.06 mg/dl) per degree Celsius.
In cystic fibrosis patients, urine osmolality was significantly higher (936.1 vs. 628.4 mOsm/kg) and less responsive (38.93 vs. 85.42 mOsm/kg) to temperature increases compared to controls.
Findings suggest that cystic fibrosis patients demonstrate less acclimatization to heat.

Abstract

The impact of long-term exposure to natural high ambient temperatures on people with cystic fibrosis (pwCF) is understudied. In a Mediterranean setting, characterized by prolonged high temperatures, we performed a pilot study to assess personal ambient temperature exposure in pwCF and healthy controls and its impact on physiological parameters. Utilizing a prospective case-control design, we recruited pwCF and paired family controls and assessed, via wearable sensors, personal temperature exposure and physical activity during three two-week periods: summer, early autumn and late autumn-early winter. After each period, key vital signs (systolic and diastolic blood pressure, heart rate, body temperature), pulmonary function, biochemical parameters (serum electrolytes, glucose, urea, creatinine, serum osmolality), and hydration status were assessed. Personal temperature exposure, daily steps and time spent indoors were similar between groups, particularly during summer. In controls, but less so in pwCF, exposure to higher temperature in the preceding days was linked to significantly lower systolic blood pressure (− 2.42 vs. − 1.53 mmHg) and serum glucose (− 5.01 vs. − 3.06 mg/dl) per degree Celsius. In pwCF, urine osmolality (936.1 vs. 628.4 mOsm/kg) was consistently higher and less responsive (38.93 vs. 85.42 mOsm/kg) per rising degree Celsius, compared to controls. In summary, despite similar personal exposures, PwCF show less profound responses after experiencing periods of heat compared to controls, in terms of lowering SBP and serum glucose and increasing urine concentration capacity, suggesting potential weaker acclimatization.

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