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May 30, 2026Open Life SciencesOpen Access

Sodium pyruvate attenuates oxidative stress, lowers ox-LDL and ox-LDL/LDL-P, and mitigates inflammation in diabetic atherosclerotic rats

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Authors

AYAhlam Mohamed YusufXCXiehui ChenMWMinmin Weng

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Overview

Randomized trial demonstrates sodium pyruvate lowers ox-LDL and inflammation in diabetic atherosclerosis, indicating potential therapeutic benefits.

Key Points

  • This research investigates the protective effects of sodium pyruvate against diabetic atherosclerosis in rats.
  • Wistar rats were divided into normal control, diabetes mellitus, diabetic atherosclerosis, and diabetic atherosclerosis treated with sodium pyruvate.
  • Serum levels of key biomarkers were measured, including malondialdehyde, ox-LDL, and inflammatory markers.
  • Comparative analysis was conducted among the control and treatment groups.
  • Sodium pyruvate treatment significantly decreased MDA (p<0.05), ox-LDL (p<0.05), ox-LDL/LDL-P ratio (p<0.05), hs-CRP (p<0.05), and IL-6 (p<0.05).
  • Sodium pyruvate increased superoxide dismutase activity compared to the diabetic atherosclerosis group (p<0.05).
  • No significant differences in RLP-C and LDL-P levels were observed between diabetic atherosclerosis and sodium pyruvate treated groups.

Cite This Study

Yusuf et al. (2026) studied this question.

synapsesocial.com/papers/6a1a81bf0307b78509433899https://doi.org/10.1515/biol-2025-1318
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