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June 15, 2026Stem Cells InternationalOpen Access

Sodium Nitrate Combined With Dental Pulp Stem Cells Alleviates Atherosclerosis Through Inhibiting Oxidative Stress

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Authors

ZMZhuang MaoHDHan DuanZHZhichao He

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Overview

Randomized trial investigates combined effects of sodium nitrate and dental pulp stem cells on atherosclerosis, showing promising cardiovascular benefits.

Key Points

  • To explore the synergistic effects of sodium nitrate and dental pulp stem cells on alleviating atherosclerosis through reducing oxidative stress.
  • ApoE −/− mice were fed a high-fat diet and treated with sodium nitrate and/or dental pulp stem cells.
  • In vitro assays examined the impact of combined treatment on oxidative stress and macrophage polarization.
  • Mechanistic studies assessed the activation of the Nrf2 signaling pathway and its role in heme oxygenase-1 regulation.
  • Combined treatment significantly reduced atherosclerotic plaque formation and oxidative stress.
  • Increased endothelial NO synthase expression and decreased circulating monocyte levels were observed.
  • Activation of the Nrf2 pathway led to the upregulation of heme oxygenase-1, enhancing antioxidant defenses.

Cite This Study

Mao et al. (2026) studied this question.

synapsesocial.com/papers/6a2f984ba1cfeec4908295c1https://doi.org/10.1155/sci/5785962
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Also Consider

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  1. 1Sodium nitrite promotes atherosclerosis via IL-1β: Network toxicology and machine learning insights2026
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