Obstetric outcomes after IVF/ICSI treatment in women with endometriosis and/or adenomyosis diagnosed by ultrasonography: a prospective cohort study

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Women with endometriosis and/or adenomyosis who conceive via IVF/ICSI have a significantly higher risk of adverse obstetric outcomes, including preterm birth, placenta previa, antepartum hemorrhage, and hypertensive disorders of pregnancy, compared to women without the disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Sara Alson; Kristina Mattsson; Povilas Sladkevicius

doi:10.1093/humrep/deag084

May 4, 2026Human ReproductionOpen Access

Obstetric outcomes after IVF/ICSI treatment in women with endometriosis and/or adenomyosis diagnosed by ultrasonography: a prospective cohort study

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Key Points

This study aims to investigate whether obstetric outcomes differ for women pregnant after IVF/ICSI diagnosed with endometriosis and/or adenomyosis compared to those without.
Prospective cohort study with 607 women who underwent IVF/ICSI treatments
Outcomes assessed included preterm birth, placenta previa, and hypertensive disorders of pregnancy
Adjusted relative risk calculated using modified Poisson regression analyses.
Preterm birth occurred in 18.9% of women with endometriosis/adenomyosis versus 11.4% in disease-free women (aRR 1.63, 95% CI 1.06-2.49, P=0.025)
Increased risk of placenta previa (aRR 5.82, P<0.001) and antepartum hemorrhage (aRR 2.02, P=0.009) in the affected group
Other risks included hypertensive disorders (aRR 2.26, P=0.004) and pelvic pain (aRR 1.91, P=0.005).

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Implication

Prospective cohort study shows increased obstetric risks in women with endometriosis and/or adenomyosis post-IVF/ICSI, indicating need for tailored care.

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Cite This Study

Alson et al. (2026) studied this question.

synapsesocial.com/papers/6a1a81bf0307b785094338ba https://doi.org/10.1093/humrep/deag084

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Obstetric outcomes after IVF/ICSI treatment in women with endometriosis and/or adenomyosis diagnosed by ultrasonography: a prospective cohort study

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

Obstetric outcomes after IVF/ICSI treatment in women with endometriosis and/or adenomyosis diagnosed by ultrasonography: a prospective cohort study

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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