Construction of a whole-course psychological nursing model and its impact on compliance with innovative drug therapy in patients with thoracic tumors: A prospective randomized controlled study.

e13544 Background: Thoracic tumors remain associated with high morbidity and mortality. With advances in precision medicine, novel agents such as Ivosidenib Injection are increasingly used in treatment. However, high cost, prolonged treatment duration, uncertain adverse effects, and concerns about prognosis often lead to anxiety and depression, resulting in poor medication adherence. Under routine nursing, the good adherence rate is only 64.00%, adversely affecting therapeutic outcomes. Therefore, evaluating the value of comprehensive whole-course psychological nursing is necessary. Methods: In this prospective randomized controlled study (May 2024–December 2025), 50 thoracic tumor patients receiving novel drug therapy for the first time were randomly assigned to an observation group or control group (n = 25 each). The control group received routine nursing, while the observation group additionally received four-stage comprehensive whole-course psychological nursing covering admission, preparation, implementation, and recovery periods. Medication adherence, psychological status, and quality of life were assessed using the Morisky Scale, SAS, SDS, and QLQ-C30 at baseline and 4 weeks. Statistical analysis was performed using SPSS 22.0. Results: All patients completed follow-up without adverse events. No significant baseline differences were observed (P > 0.05). After 4 weeks, the observation group showed higher adherence (88.00% vs 64.00%), lower anxiety and depression scores, and better QLQ-C30 functional outcomes than the control group (P < 0.05). Conclusions: Comprehensive whole-course psychological nursing effectively reduces negative emotions, improves adherence to novel drug therapy, and enhances quality of life in thoracic tumor patients, demonstrating substantial clinical value. Integrated core data table. Group Sample Size Post-intervention Good Adherence Rate Post-intervention SAS Score mean±SD Post-intervention SDS Score mean±SD Post-intervention Physical Function Score mean±SD P Value Observation Group 25 88.00 50.13±2.33 54.86±2.10 82.00±5.96 <0.05 Control Group 25 64.00 53.00±2.10 57.73±3.52 74.93±3.13 <0.05 Post-intervention core indicators significant intergroup differences.