What question did this study set out to answer?

To sequence and characterize the genomic regions of Kaposi's sarcoma-associated herpesvirus (KSHV) to identify potential viral oncogenes driving disease pathogenesis.

November 1, 1996Journal of VirologyOpen Access

Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma

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Authors

ECEthel CesarmanCornell University RNRoland G. NádorUniversity of British Columbia FBFengju BaiCharles River Laboratories (Netherlands)

Discussion

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Implication

Molecular study reveals active transcription of viral cyclin D and GPCR homologs in Kaposi's sarcoma, suggesting an oncogenic role in malignant transformation.

Key Points

To sequence and characterize the genomic regions of Kaposi's sarcoma-associated herpesvirus (KSHV) to identify potential viral oncogenes driving disease pathogenesis.
Isolated and sequenced a 12.3-kb KSHV genomic clone from a primary effusion lymphoma (PEL) genomic library.
Analyzed sequence colinearity and homology relative to herpesvirus saimiri (HVS) and Epstein-Barr virus (EBV).
Assessed the transcriptional activity of identified open reading frames (ORFs) across PEL and Kaposi's sarcoma tissues.
Identified four distinct viral ORFs homologous to viral and cellular genes, including cyclin D, G protein-coupled receptors, and EBV/HVS membrane antigens.
Demonstrated active transcription of all four identified ORFs in both primary effusion lymphomas and Kaposi's sarcoma tumor tissues.

Cite This Study

Cesarman et al. (1996) studied this question.

synapsesocial.com/papers/6a1a84e5837f1a2c63b8ba2c https://doi.org/10.1128/jvi.70.11.8218-8223.1996

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Implication

Molecular study reveals active transcription of viral cyclin D and GPCR homologs in Kaposi's sarcoma, suggesting an oncogenic role in malignant transformation.

Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma

Discussion

Member takes

Implication

Key Points

Cite This Study

Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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