Why the study?
This study was conducted to assess the influence of early hyperlactatemia after transcatheter aortic valve implantation (TAVI) on subsequent outcomes.
Does peak post-procedure lactate level within 24 hours predict 30-day mortality in adult patients undergoing elective percutaneous TAVI?
Does peak post-procedure lactate level within 24 hours predict 30-day mortality in adult patients undergoing elective percutaneous TAVI?
Early hyperlactatemia (peak >1.54 mmol/L within 24 hours) after TAVI is a useful predictor of 30-day mortality.
May support post-TAVI lactate monitoring for risk stratification; hypothesis-generating and requires prospective validation before practice change.
BACKGROUND: This study assesses the influence of early hyperlactatemia after the transcatheter aortic valve implantation (TAVI) procedure on subsequent outcomes. METHODS: Adult patients undergoing elective percutaneous TAVI between 2012 and 2022 in a single tertiary cardiac center were retrospectively included. Peak post-procedure lactate level within 24-h was recorded for 284 patients included in the study. The primary outcome measured was 30-day mortality. ROC analysis revealed 1.54 mmol/L as a cutoff for mortality with 85.7% specificity and 68.4% sensitivity. CONCLUSION: The initial 24-hour lactate levels seem to play a valuable role in predicting the likelihood of surviving during the hospital stay after the implantation procedure. Further investigation is required to ascertain the optimal strategies for managing early post-procedure hyperlactatemia in the TAVI population.
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Uzman et al. (2025) studied this question.
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