Role of Reversible Oxidation-Reduction of Enzyme Thiols-Disulfides in Metabolic Regulation

Daniel M. Ziegler

doi:10.1146/annurev.bi.54.070185.001513

June 1, 1985Annual Review of Biochemistry

Role of Reversible Oxidation-Reduction of Enzyme Thiols-Disulfides in Metabolic Regulation

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Key Points

To examine the roles of conserved signaling cascades and reversible enzyme oxidation-reduction in cellular growth and metabolic regulation.
Reviewed cellular regulatory cascades, including the Hippo signaling pathway in Drosophila melanogaster.
Evaluated the biochemical role of reversible thiol-disulfide switches in metabolic enzyme activity.
The Hippo pathway is established as an evolutionarily conserved cascade orchestrating cell fate, tissue growth, and organ dimensions.
Reversible oxidation-reduction of enzyme thiols serves as a key biochemical mechanism governing metabolic adaptation.

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Implication

Review describes the signaling and redox mechanisms controlling cellular growth and organ size, highlighting pathways essential for metabolic regulation.

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Daniel M. Ziegler (1985) studied this question.

synapsesocial.com/papers/6a1a94724dcca27063858fa0 https://doi.org/10.1146/annurev.bi.54.070185.001513

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Role of Reversible Oxidation-Reduction of Enzyme Thiols-Disulfides in Metabolic Regulation

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Role of Reversible Oxidation-Reduction of Enzyme Thiols-Disulfides in Metabolic Regulation

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