High Plasma Aldosterone Levels on Admission Are Associated With Death in Patients Presenting With Acute ST-Elevation Myocardial Infarction
Why the study?
Are high plasma aldosterone levels on admission associated with increased mortality and adverse events in patients with STEMI?
Population
356 consecutive patients presenting with acute ST-elevation myocardial infarction referred for primary…
Comparison
High plasma aldosterone levels on admission vs Low plasma aldosterone levels on admission
Design
Cohort
Follow-up
6 months
Authors
Discussion
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Member takes
Implication
High aldosterone on STEMI admission identifies higher short-term mortality risk; hypothesis-generating for early blockade, pending prospective trials.
Structured PICO
Are high plasma aldosterone levels on admission associated with increased mortality and adverse events in patients with STEMI?
P
Population
356 consecutive patients presenting with acute ST-elevation myocardial infarction (STEMI) referred for primary percutaneous coronary intervention
I
Intervention
High plasma aldosterone levels on admission (highest quartile)
C
Comparator
Low plasma aldosterone levels on admission (first quartile)
O
Outcome
In-hospital events and mortality during a 6-month follow-uphard clinical
High plasma aldosterone levels on admission in STEMI patients are independently associated with increased early and late mortality, suggesting a potential role for early aldosterone antagonist administration.
Cite This Study
Beygui et al. (2006) studied this question.