Why the study?
Does KCNQ1 deficiency improve insulin sensitivity and glucose metabolism in mice?
Population
KCNQ1-deficient mice (kcnq1(-/-)) and their wild-type littermates (kcnq1(+/+))
Comparison
KCNQ1 gene deficiency vs Wild-type littermates (kcnq1(+/+))
Design
Preclinical
Authors
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KCNQ1 deficiency improves insulin sensitivity in mice; leaves open applicability to human metabolic disease.
Does KCNQ1 deficiency improve insulin sensitivity and glucose metabolism in mice?
KCNQ1 deficiency enhances insulin sensitivity and glucose metabolism in mice, identifying KCNQ1 as a novel regulator of insulin signaling.
Boini et al. (2009) studied this question.
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